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HIV-1 infections with multiple founders are associated with higher viral loads than infections with single founders

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dc.contributor.authorHolly Janesen_US
dc.contributor.authorJoshua T. Herbecken_US
dc.contributor.authorSodsai Tovanabutraen_US
dc.contributor.authorRasmi Thomasen_US
dc.contributor.authorNicole Frahmen_US
dc.contributor.authorAnn Duerren_US
dc.contributor.authorJohn Huralen_US
dc.contributor.authorLawrence Coreyen_US
dc.contributor.authorSteve G. Selfen_US
dc.contributor.authorSusan P. Buchbinderen_US
dc.contributor.authorM. Juliana McElrathen_US
dc.contributor.authorRobert J. O'Connellen_US
dc.contributor.authorRobert M. Parisen_US
dc.contributor.authorSupachai Rerks-Ngarmen_US
dc.contributor.authorSorachai Nitayaphanen_US
dc.contributor.authorPunnee Pitisuttihumen_US
dc.contributor.authorJaranit Kaewkungwalen_US
dc.contributor.authorMerlin L. Robben_US
dc.contributor.authorNelson L. Michaelen_US
dc.contributor.authorJames I. Mullinsen_US
dc.contributor.authorJerome H. Kimen_US
dc.contributor.authorPeter B. Gilberten_US
dc.contributor.authorMorgane Rollanden_US
dc.contributor.otherFred Hutchinson Cancer Research Centeren_US
dc.contributor.otherUniversity of Washington, Seattleen_US
dc.contributor.otherWalter Reed Army Institute of Researchen_US
dc.contributor.otherHJFen_US
dc.contributor.otherArmed Forces Research Institute of Medical Sciences, Thailanden_US
dc.contributor.otherThailand Ministry of Public Healthen_US
dc.contributor.otherMahidol Universityen_US
dc.date.accessioned2018-11-23T09:38:13Z
dc.date.available2018-11-23T09:38:13Z
dc.date.issued2015-10-01en_US
dc.description.abstract© 2015 Nature America, Inc. All rights reserved. Given the variation in the HIV-1 viral load (VL) set point across subjects, as opposed to a fairly stable VL over time within an infected individual, it is important to identify the characteristics of the host and virus that affect VL set point. Although recently infected individuals with multiple phylogenetically linked HIV-1 founder variants represent a minority of HIV-1 infections, we found - in two different cohorts - that more diverse HIV-1 populations in early infection were associated with significantly higher VL 1 year after HIV-1 diagnosis.en_US
dc.identifier.citationNature Medicine. Vol.21, No.10 (2015), 1139-1141en_US
dc.identifier.doi10.1038/nm.3932en_US
dc.identifier.issn1546170Xen_US
dc.identifier.issn10788956en_US
dc.identifier.other2-s2.0-84943663211en_US
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/20.500.14594/35376
dc.rightsMahidol Universityen_US
dc.rights.holderSCOPUSen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84943663211&origin=inwarden_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.titleHIV-1 infections with multiple founders are associated with higher viral loads than infections with single foundersen_US
dc.typeArticleen_US
dspace.entity.typePublication
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84943663211&origin=inwarden_US

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