Publication: Preparation of [4‐<sup>3</sup>H]‐3‐dehydroretinol by sodium borotritide reduction
Issued Date
1985-01-01
Resource Type
ISSN
10991344
03624803
03624803
Other identifier(s)
2-s2.0-0021829501
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Labelled Compounds and Radiopharmaceuticals. Vol.22, No.9 (1985), 925-930
Suggested Citation
Pichit Tosukhowong, Thararat Supasiri Preparation of [4‐<sup>3</sup>H]‐3‐dehydroretinol by sodium borotritide reduction. Journal of Labelled Compounds and Radiopharmaceuticals. Vol.22, No.9 (1985), 925-930. doi:10.1002/jlcr.2580220908 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/30754
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Title
Preparation of [4‐<sup>3</sup>H]‐3‐dehydroretinol by sodium borotritide reduction
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Abstract
[4‐3H]‐Dehydroretinol (5) was prepared from a vitamin A derivative. The procedure involves conversion of methyl retinoate (1) to methyl 4‐oxoretinoate (2) by manganes dioxide oxidation. The 3H‐label was introduced by sodium borotritide reduction of methyl 4‐oxoretinoate (2) followed by acid catalyzed dehyration to methyl [4‐3H]‐3‐dehydroretinoate (4). Reduction of the tritiated methyl dehydroretinoate with lithium aluminium hydride yielded [4‐3H]‐3‐dehydroretinol (5). Final purification was achieved by preparative thin layer chromatography. Copyright © 1985 John Wiley & Sons, Ltd.