Publication: Size-dependent cytotoxicity of copper oxide nanoparticles in lung epithelial cells
Issued Date
2016-01-01
Resource Type
ISSN
20518161
20518153
20518153
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2-s2.0-84964612040
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Mahidol University
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SCOPUS
Bibliographic Citation
Environmental Science: Nano. Vol.3, No.2 (2016), 365-374
Suggested Citation
Amaraporn Wongrakpanich, Imali A. Mudunkotuwa, Sean M. Geary, Angie S. Morris, Kranti A. Mapuskar, Douglas R. Spitz, Vicki H. Grassian, Aliasger K. Salem Size-dependent cytotoxicity of copper oxide nanoparticles in lung epithelial cells. Environmental Science: Nano. Vol.3, No.2 (2016), 365-374. doi:10.1039/c5en00271k Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/40623
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Title
Size-dependent cytotoxicity of copper oxide nanoparticles in lung epithelial cells
Abstract
© 2016 The Royal Society of Chemistry. The increasing use of copper oxide (CuO) nanoparticles (NPs) in medicine and industry demands an understanding of their potential toxicities. In this study, we compared the in vitro cytotoxicity of CuO NPs of two distinct sizes (4 and 24 nm) using the A549 human lung cell line. Despite possessing similar surface and core oxide compositions, 24 nm CuO NPs were significantly more cytotoxic than 4 nm CuO NPs. The difference in size may have affected the rate of entry of NPs into the cell, potentially influencing the amount of intracellular dissolution of Cu2+and causing a differential impact on cytotoxicity.