Publication: Anti-metastatic effects of aqueous extract of Helixanthera parasitica
Issued Date
2003-01-01
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ISSN
03788741
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2-s2.0-0038301113
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Ethnopharmacology. Vol.86, No.2-3 (2003), 253-256
Suggested Citation
Kriengsak Lirdprapamongkol, Chulabhorn Mahidol, Sanit Thongnest, Hunsa Prawat, Somsak Ruchirawat, Chantragan Srisomsap, Rudee Surarit, Phaibul Punyarit, Jisnuson Svasti Anti-metastatic effects of aqueous extract of Helixanthera parasitica. Journal of Ethnopharmacology. Vol.86, No.2-3 (2003), 253-256. doi:10.1016/S0378-8741(03)00072-2 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/21038
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Title
Anti-metastatic effects of aqueous extract of Helixanthera parasitica
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Abstract
Metastasis, the spread of cancer in body, is a major cause of death. We have screened anti-metastatic activity of aqueous and dichloromethane extracts of several not previously studied Thai herbs, using an in vitro invasion test. This involves the in vitro invasion of HCC-S102, a hepatocellular carcinoma cell line derived from a Thai patient, through a reconstituted-basement membrane (Matrigel). The aqueous extract of a plant (Helixanthera parasitica) revealed a significant inhibitory effect on the cancer cell invasion, and showed antioxidant activity. The aqueous extract was partially purified by silica gel column chromatography, and the highest anti-metastatic activity fraction showed 83% inhibition of invasion with low cytotoxic effect. However, anti-metastatic activity was not associated with the antioxidant activity of the aqueous extract. © 2003 Elsevier Science Ireland Ltd. All rights reserved.