Publication: Anti-metastatic effects of aqueous extract of Helixanthera parasitica
| dc.contributor.author | Kriengsak Lirdprapamongkol | en_US |
| dc.contributor.author | Chulabhorn Mahidol | en_US |
| dc.contributor.author | Sanit Thongnest | en_US |
| dc.contributor.author | Hunsa Prawat | en_US |
| dc.contributor.author | Somsak Ruchirawat | en_US |
| dc.contributor.author | Chantragan Srisomsap | en_US |
| dc.contributor.author | Rudee Surarit | en_US |
| dc.contributor.author | Phaibul Punyarit | en_US |
| dc.contributor.author | Jisnuson Svasti | en_US |
| dc.contributor.other | Chulabhorn Research Institute | en_US |
| dc.contributor.other | Mahidol University | en_US |
| dc.contributor.other | Phramongkutklao College of Medicine | en_US |
| dc.date.accessioned | 2018-07-24T03:29:45Z | |
| dc.date.available | 2018-07-24T03:29:45Z | |
| dc.date.issued | 2003-01-01 | en_US |
| dc.description.abstract | Metastasis, the spread of cancer in body, is a major cause of death. We have screened anti-metastatic activity of aqueous and dichloromethane extracts of several not previously studied Thai herbs, using an in vitro invasion test. This involves the in vitro invasion of HCC-S102, a hepatocellular carcinoma cell line derived from a Thai patient, through a reconstituted-basement membrane (Matrigel). The aqueous extract of a plant (Helixanthera parasitica) revealed a significant inhibitory effect on the cancer cell invasion, and showed antioxidant activity. The aqueous extract was partially purified by silica gel column chromatography, and the highest anti-metastatic activity fraction showed 83% inhibition of invasion with low cytotoxic effect. However, anti-metastatic activity was not associated with the antioxidant activity of the aqueous extract. © 2003 Elsevier Science Ireland Ltd. All rights reserved. | en_US |
| dc.identifier.citation | Journal of Ethnopharmacology. Vol.86, No.2-3 (2003), 253-256 | en_US |
| dc.identifier.doi | 10.1016/S0378-8741(03)00072-2 | en_US |
| dc.identifier.issn | 03788741 | en_US |
| dc.identifier.other | 2-s2.0-0038301113 | en_US |
| dc.identifier.uri | https://repository.li.mahidol.ac.th/handle/20.500.14594/21038 | |
| dc.rights | Mahidol University | en_US |
| dc.rights.holder | SCOPUS | en_US |
| dc.source.uri | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0038301113&origin=inward | en_US |
| dc.subject | Pharmacology, Toxicology and Pharmaceutics | en_US |
| dc.title | Anti-metastatic effects of aqueous extract of Helixanthera parasitica | en_US |
| dc.type | Article | en_US |
| dspace.entity.type | Publication | |
| mu.datasource.scopus | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0038301113&origin=inward | en_US |
