Publication: Intestinal epithelium brush border and microsome chemistry. I. Crude cholera toxin effects
Issued Date
1972-01-01
Resource Type
ISSN
10960945
00144800
00144800
Other identifier(s)
2-s2.0-0015418552
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Mahidol University
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SCOPUS
Bibliographic Citation
Experimental and Molecular Pathology. Vol.17, No.2 (1972), 187-197
Suggested Citation
Gordon J. Leitch Intestinal epithelium brush border and microsome chemistry. I. Crude cholera toxin effects. Experimental and Molecular Pathology. Vol.17, No.2 (1972), 187-197. doi:10.1016/0014-4800(72)90068-8 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/10003
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Title
Intestinal epithelium brush border and microsome chemistry. I. Crude cholera toxin effects
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Abstract
Sucrase, trehalase and aryl amidase are most probably located on the luminal surface of the intestinal microvilli, while sialic acids are found in glycoproteins in the glycocalyx and elsewhere on the cell surface. Phospholipids, cholesterol and glycolipids probably constitute the plasma membrane core. Exposure of the intestinal lumen surface to crude cholera toxin resulted in significant reductions in brush border and microsome sialic acids, phospholipids and cholesterol: protein ratios and brush border glycolipids: protein ratios. Cholera toxin had only minor effects on the three brush border enzymes. The toxin neuraminidase activity was insufficient to account for the observed effects on membrane sialic acids. © 1972.