The acute stimulatory effect of prolaction on active calcium absorption in rat intestine
1
Issued Date
2024
Copyright Date
1992
Resource Type
Language
eng
File Type
application/pdf
No. of Pages/File Size
xvi, 150 leaves : ill.
Access Rights
open access
Rights
ผลงานนี้เป็นลิขสิทธิ์ของมหาวิทยาลัยมหิดล ขอสงวนไว้สำหรับเพื่อการศึกษาเท่านั้น ต้องอ้างอิงแหล่งที่มา ห้ามดัดแปลงเนื้อหา และห้ามนำไปใช้เพื่อการค้า
Rights Holder(s)
Mahidol University
Bibliographic Citation
Thesis (M.Sc. (Physiology))--Mahidol University, 1992
Suggested Citation
Premtip Thaveeratitham The acute stimulatory effect of prolaction on active calcium absorption in rat intestine. Thesis (M.Sc. (Physiology))--Mahidol University, 1992. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/100273
Title
The acute stimulatory effect of prolaction on active calcium absorption in rat intestine
Alternative Title(s)
ผลเฉียบพลันของโพรแลคตินต่อการดูดซึมแคลเซี่ยมแบบแอคทีฟที่ลำไส้
Author(s)
Abstract
The acute effect of prolactin on active calcium absorption was investigated in weaned, young, sexually mature and aged female Wistar rats by using everted gut sac technique. The serosal/mucosal or [S]/[M] ratio of 45Ca concentration was used as an index of active calcium transport. The data showed that intraperitoneal injection of 0.02 mg prolactin/100 g BW, 5 and 10 minutes before experiment could increase the active calcium transport in the duodenum but not other intestinal segments of sexual rats. However, prolactin had no effect on duodenal active calcium transport in weaned, young and aged rats. The mechanism of action prolactin on active calcium absorption was investigated by determining the effect of prolactin on transapical uptake of calcium across the oil-filled duodenal sac in 2 minutes also demonstrated. It was found that intraperitoneal injection of 0.02 mg prolactin/100 g BW, 5 minutes before the uptake experiment could enhance the transapical calcium uptake. These data indicated that acute effect of prolactin on active calcium absorption was nongenomic and not mediated by enhanced production of 1,25(0H)2D3. Prolactin increased active calcium absorption partly by stimulating the transapical calcium uptake across the brush border membrane by as yet enhance mechanism.
Description
Physiology (Mahidol University 1992)
Degree Name
Master of Science
Degree Level
Master's degree
Degree Department
Faculty of Science
Degree Discipline
Physiology
Degree Grantor(s)
Mahidol University