The significance of various intestinal segments in the regulation of plasma calcium concentration
3
Issued Date
2024
Copyright Date
1991
Resource Type
Language
eng
File Type
application/pdf
No. of Pages/File Size
xvi, 123 leaves : ill.
Access Rights
open access
Rights
ผลงานนี้เป็นลิขสิทธิ์ของมหาวิทยาลัยมหิดล ขอสงวนไว้สำหรับเพื่อการศึกษาเท่านั้น ต้องอ้างอิงแหล่งที่มา ห้ามดัดแปลงเนื้อหา และห้ามนำไปใช้เพื่อการค้า
Rights Holder(s)
Mahidol University
Bibliographic Citation
Thesis (M.Sc. (Physiology))--Mahidol University, 1991
Suggested Citation
Thitinad Deenoi The significance of various intestinal segments in the regulation of plasma calcium concentration. Thesis (M.Sc. (Physiology))--Mahidol University, 1991. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/100345
Title
The significance of various intestinal segments in the regulation of plasma calcium concentration
Alternative Title(s)
ความสำคัญของลำไส้ส่วนต่าง ๆ ในการช่วยควบคุมระดับแคลเซียมในเลือด
Author(s)
Abstract
Different segments of the intestine have different absorptive and secretory rates of Ca which may change according to physiological conditions. It was interesting to evaluate possible role of the intestine in acute regulation of plasma Ca level by observing changes in Ca transport after functional resection of certain intestinal segments. For absorption study, absorbed Ca was calculated from the diffrence between administered (45)Ca and final luminal (45)Ca content. Calcium secretion was represented by luminal (45)Ca contents 60 min after iv injection of (45)CaCl(,2). Results showed that with luminal Ca of 0.3 or 10 mM, resection of duodenum or duodenum+proximal jejunum or colon or distal ileum+caecum+colon did not affect total Ca absorption. In contrast, Ca secretion was significantly reduced with intestinal resection. Ca absorption was found to increase during hypercalcaemia and thyroparathyroidectomy-induced hypocalcaemia. Ca secretion, on the other hand, was directly related to plasma Ca concentration. It was further demonstrated that during hypercalcaemia, the proximal colon was partly responsible for increase in Ca secretion. It could be concluded that (i) the intestine exhibited redundancy in Ca absorption and (ii) that the apparent increase in Ca absorption and reduced secretion during hypocalcaemia and increased secretion during hypercalcaemia may help to normalize or prevent further change in plasma Ca concentration.
Description
Physiology (Mahidol University 1991)
Degree Name
Master of Science
Degree Level
Master's degree
Degree Department
Faculty of Science
Degree Discipline
Physiology
Degree Grantor(s)
Mahidol University