Optimization of diformylfuran production from 5-hydroxymethylfurfural via catalytic oxidation in a packed-bed continuous flow reactor
Issued Date
2024-09-12
Resource Type
eISSN
20462069
Scopus ID
2-s2.0-85204230679
Journal Title
RSC Advances
Volume
14
Issue
40
Start Page
29014
End Page
29023
Rights Holder(s)
SCOPUS
Bibliographic Citation
RSC Advances Vol.14 No.40 (2024) , 29014-29023
Suggested Citation
Pumrod S., Akkarawatkhoosith N., Kaewchada A., Tongtummachat T., Andrew Lin K.Y., Jaree A. Optimization of diformylfuran production from 5-hydroxymethylfurfural via catalytic oxidation in a packed-bed continuous flow reactor. RSC Advances Vol.14 No.40 (2024) , 29014-29023. 29023. doi:10.1039/d4ra05816j Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/101347
Title
Optimization of diformylfuran production from 5-hydroxymethylfurfural via catalytic oxidation in a packed-bed continuous flow reactor
Corresponding Author(s)
Other Contributor(s)
Abstract
DFF's diverse applications in pharmaceuticals, fungicides, and polymer synthesis motivate the development of efficient production methods. This study reports the continuous-flow synthesis of DFF from 5-HMF in a packed-bed reactor. The Box-Behnken design coupled with response surface methodology (RSM) was employed to optimize the reaction parameters (catalyst, solvent, temperature, oxygen flow rate, catalyst amount) for DFF yield. Ru/Al2O3 in toluene proved to be the most effective catalyst-solvent combination. The optimal conditions for DFF production were identified as: 140 °C reaction temperature, 10 ml min−1 oxygen flow rate, and 0.15 g catalyst loading. Under these conditions, a DFF yield of 84.2% was achieved.