Cordycepin exhibits both antiviral and anti-inflammatory effects against dengue virus infection
Issued Date
2024-09-20
Resource Type
eISSN
25890042
Scopus ID
2-s2.0-85207773898
Journal Title
iScience
Volume
27
Issue
9
Rights Holder(s)
SCOPUS
Bibliographic Citation
iScience Vol.27 No.9 (2024)
Suggested Citation
Songprakhon P., Panya A., Choomee K., Limjindaporn T., Noisakran S., Tarasuk M., Yenchitsomanus P.t. Cordycepin exhibits both antiviral and anti-inflammatory effects against dengue virus infection. iScience Vol.27 No.9 (2024). doi:10.1016/j.isci.2024.110711 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/101929
Title
Cordycepin exhibits both antiviral and anti-inflammatory effects against dengue virus infection
Corresponding Author(s)
Other Contributor(s)
Abstract
Cordycepin, a natural derivative of adenosine from Cordyceps militaris, can inhibit the replication of the dengue virus (DENV). Here, we investigated its antiviral and anti-inflammatory effects in DENV infected cells. Cordycepin significantly inhibited DENV-2 infection, virion production, and viral protein synthesis. It also reduced DENV-induced cytokine/chemokine production, including RANTES, IP-10, IL-6, and TNF-α. Mechanistically, cordycepin targeted the DENV NS5 protein, suppressing RANTES expression and hindering viral replication. Additionally, it inhibited the NF-κB pathway, leading to reduced nuclear translocation and signaling deactivation. PCR array analysis revealed cordycepin's suppression of 46 genes associated with DENV-induced inflammation. These findings highlight cordycepin's dual potential as an antiviral and anti-inflammatory agent against DENV, making it as a promising candidate for dengue treatment, targeting both viral and host factors.