Minimal important changes of HFS-30 and HFS-7 questionnaires for patients with hemifacial spasm
2
Issued Date
2025-01-01
Resource Type
eISSN
25901125
Scopus ID
2-s2.0-85212627359
Journal Title
Clinical Parkinsonism and Related Disorders
Volume
12
Rights Holder(s)
SCOPUS
Bibliographic Citation
Clinical Parkinsonism and Related Disorders Vol.12 (2025)
Suggested Citation
Saengphatrachai W., Inthapong N., Pitakpatapee Y., Rattanathamsakul N., Srivanitchapoom P. Minimal important changes of HFS-30 and HFS-7 questionnaires for patients with hemifacial spasm. Clinical Parkinsonism and Related Disorders Vol.12 (2025). doi:10.1016/j.prdoa.2024.100295 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/103015
Title
Minimal important changes of HFS-30 and HFS-7 questionnaires for patients with hemifacial spasm
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Abstract
Introduction: Hemifacial spasm (HFS) significantly reduces health-related quality of life (HRQoL). Currently, the HFS-30 and HFS-7 questionnaires are used to evaluate the HRQoL in HFS patients; however, their minimal important changes (MICs) have not yet to be established. This study aimed to determine the MICs for HFS-30 and HFS-7 and patients’ characteristics associated with them. Methods: Data were prospectively collected from HFS patients aged ≥18 years at a botulinum toxin clinic in a single tertiary university hospital between April 2022 and April 2023. We assessed HFS-30 and HFS-7 scores, Samsung Medical Center (SMC) grades, Patient Health Questionnaire-9 (PHQ-9) scores, and patient-reported HRQoL global rating of change scores at baseline, followed by assessments every two days for two weeks and at the one-month follow-up. MICs were determined based on the first follow-up visit when patients reported minimal improvement. Results: The 112 enrolled patients had a median age of 62.8 years (IQR: 56.6–69.3) and a median disease duration of 10 years (IQR: 4–17). The MICs of the HFS-30 and HFS-7 questionnaires were −4.55 points (95 % CI: −5.49 to −3.62) and −0.96 points (95 % CI: −1.28 to −0.64), respectively. Patients with moderate-to-severe depression reported significantly greater MICs than those with milder depression (p < 0.001). Patients aged less than 60 had significantly greater MICs than older patients (p = 0.045). Conclusions: The MICs of the HFS-30 and HFS-7 questionnaires were −4.55 and −0.96, respectively. The MIC is substantially greater in HFS patients with moderate-to-severe depression and younger age.