Effect of praziquantel on the structure of liver and small intestine in mice
1
Issued Date
1991
Copyright Date
1991
Resource Type
Language
eng
File Type
application/pdf
No. of Pages/File Size
vii, 136 leaves : ill.
Access Rights
open access
Rights
ผลงานนี้เป็นลิขสิทธิ์ของมหาวิทยาลัยมหิดล ขอสงวนไว้สำหรับเพื่อการศึกษาเท่านั้น ต้องอ้างอิงแหล่งที่มา ห้ามดัดแปลงเนื้อหา และห้ามนำไปใช้เพื่อการค้า
Rights Holder(s)
Mahidol University
Bibliographic Citation
Thesis (M.Sc. (Anatomy))--Mahidol University, 1991
Suggested Citation
Kledkaew Panyong Effect of praziquantel on the structure of liver and small intestine in mice. Thesis (M.Sc. (Anatomy))--Mahidol University, 1991. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/103306
Title
Effect of praziquantel on the structure of liver and small intestine in mice
Alternative Title(s)
ผลของยาพราซิควอนเทลต่อโครงสร้างของตับและลำไส้เล็กในหนูทดลอง
Author(s)
Advisor(s)
Abstract
The histological and ultrastructural changes occurring in the liver and small intestine of mice were examined by light and transmission electron microscopy, following the oral administration of praziquantel at the dosages of 250 mg/kg/day for 5 and 10 days and a single dose of 1250 mg/kg/day. Reversible signs of injury were observed in liver cells, following praziquantel administration at the dose 250 mg/kg/day for 10 days. These changes were partial depolymerization of the cytoskeletal network, vesiculation and dilatation of RER, proliferation of SER, glycogen depletion and chromatin clumping. In contrast, more severe and irreversible changes in the liver cells were observed at a single oral dose of 1250 mg/kg/day, they consisted of the accumulation of lipid droplets, mitochondrial swelling, degeneration and clumping of chromatin and the presence of intranuclear inclusions. In comparison to the liver cells, the intestinal epithelial cells showed only mild degenerative changes consisting of decreased cytoplasmic density, dilatation of RER, swelling of mitochondria and presence of multivesicular bodies and mvelin - like figures. These changes occurred only in the epithelial cells covering the lower part of villi while those on the upper part remained intact.
Description
Anatomy (Mahidol University 1991)
Degree Name
Master of Science
Degree Level
Master's degree
Degree Department
Faculty of Science
Degree Discipline
Anatomy
Degree Grantor(s)
Mahidol University