Effects of melatonin on accessory sex glands in testosterone-treated, orchidectomized rats
1
Issued Date
1988
Copyright Date
1988
Resource Type
Language
eng
File Type
application/pdf
No. of Pages/File Size
viii, 50 leaves : ill.
Access Rights
open access
Rights
ผลงานนี้เป็นลิขสิทธิ์ของมหาวิทยาลัยมหิดล ขอสงวนไว้สำหรับเพื่อการศึกษาเท่านั้น ต้องอ้างอิงแหล่งที่มา ห้ามดัดแปลงเนื้อหา และห้ามนำไปใช้เพื่อการค้า
Rights Holder(s)
Mahidol University
Bibliographic Citation
Thesis (M.Sc. (Anatomy))--Mahidol University, 1988
Suggested Citation
Nisaudah Radenahmad Effects of melatonin on accessory sex glands in testosterone-treated, orchidectomized rats. Thesis (M.Sc. (Anatomy))--Mahidol University, 1988. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/103330
Title
Effects of melatonin on accessory sex glands in testosterone-treated, orchidectomized rats
Alternative Title(s)
ผลของเมลาโทนินต่อต่อมเพศของหนูที่ถูกตัดลูกฉัณฑะและได้รับการเสริมด้วยฮอร์โมนเทสเตอโรน
Author(s)
Advisor(s)
Abstract
Melatonin has been shown to directly affect gross and micro-scopic features of rat ventral prostate. The purpose of this study is to further elucidate its direct action on rat seminal vesicle, ventral prostate, dorsolateral prostate, and coagulating gland in terms of tissue weights and their citric acid and fructose contents. Rats were divided into sham-orchidectomized (SO), orchidectomized (O), testoster-one-treated orchidectomized (OT), and combined melatonin, testosterone-treated, orchidectomized groups. The group was further divided into the 50 ?g melatonin-treated group (OTM50) and the 400 ?g melatonin-treated group (OTM400). After 4 weeks of treatments, the rats were decapitated sera were collected for testosterone radioimmunoassay the organs were removed, weighed, and biochemically assayed. The organ weights, citric acid contents, fructose contents, and testosterone concentrations did not differ in the OT, OTM50 and OTM400 animals. Attempts to correlate between the weights of the organs and serum testosterone levels revealed that no such correlation existed in the OT animals. Whereas the negative correlation was found between the weights of coagulating gland, as well as the dorsolateral prostate, and serum testosterone levels in the melatonin-treated animals. Negative correlation was also found between citric acid concentration in the ventral prostate of the OTM50 animals and their serum testosterone levels. These results suggest that melatonin has a limited direct action on rat accessory sex organs it does not produce dramatic changes in weights and biochemistry but rather modifies the effects of testosterone on these organs.
Description
Anatomy (Mahidol University 1988)
Degree Name
Master of Science
Degree Level
Master's degree
Degree Department
Faculty of Science
Degree Discipline
Anatomy
Degree Grantor(s)
Mahidol University