Publication: Selective activation of cardiovascular adenylate cyclase in vivo
Issued Date
1977-01-01
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ISSN
00039780
Other identifier(s)
2-s2.0-0017326382
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Mahidol University
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SCOPUS
Bibliographic Citation
Archives Internationales de Pharmacodynamie et de Therapie. Vol.225, No.1 (1977), 98-103
Suggested Citation
S. Phornchirasilp, R. Lockwood Selective activation of cardiovascular adenylate cyclase in vivo. Archives Internationales de Pharmacodynamie et de Therapie. Vol.225, No.1 (1977), 98-103. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/10338
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Title
Selective activation of cardiovascular adenylate cyclase in vivo
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Abstract
Cyclic AMP levels were measured in cardiac and vascular tissues removed from pentobarbitone anesthetized rats pretreated with theophylline 45 mg/kg i.p. Noradrenaline, 20 μg/kg i.v., increased cardiac but not vascular cyclic AMP levels; this selective effect of noradrenaline was not altered by pretreatment with phenoxybenzamine, 1 mg/kg i.v. Tazolol, 120 μg/kg i.v., selectively increased cardiac cyclic AMP levels whereas fenoterol, 15 μg/kg i.v., selectively increased vascular cyclic AMP levels. The results suggest that adenylate cyclase activation in cardiac and vascular tissues in vivo is mediated by beta adrenoceptors which consist of different subtypes.