Publication: Secretory and serum IgA in children with protein calorie malnutrition
1
Issued Date
1975-12-01
Resource Type
ISSN
00314005
Other identifier(s)
2-s2.0-0016683521
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Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Pediatrics. Vol.55, No.2 (1975), 166-170
Suggested Citation
S. Sirisinha, R. Suskind, R. Edelman, C. Asvapaka, R. E. Olson Secretory and serum IgA in children with protein calorie malnutrition. Pediatrics. Vol.55, No.2 (1975), 166-170. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/10793
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Title
Secretory and serum IgA in children with protein calorie malnutrition
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Abstract
The local immune system of children with protein calorie malnutrition (PCM) was investigated by analyzing the amount of immunoglobulins in the nasal washing, repeatedly during 84 days of hospital therapy, and on follow up, one to two years later. Although measured concentrations of total protein, IgG, and albumin in nasal washings were reduced in children with PCM, only secretory IgA concentrations were significantly lower (P < .01) in PCM compared to normal children. Mean secretory IgA concentrations were significantly reduced through hospital day 70 and returned to near normal thereafter. At one to two years after hospital discharge, mean concentrations of secretory IgA in nasal secretions were within normal limits. The concentrations of secretory IgA in nasal washings were lowest at a time when serum IgA was markedly elevated; serum IgA concentrations fell to normal values during dietary treatment. The possible role of secretory IgA deficiency in PCM and infection is discussed.