The Role of Human Papillomavirus in Oral Potentially Malignant Disorders and Cancer: A Review Literature
Issued Date
2025-04-01
Resource Type
eISSN
28220838
Scopus ID
2-s2.0-105002668146
Journal Title
Natural and Life Sciences Communications
Volume
24
Issue
2
Rights Holder(s)
SCOPUS
Bibliographic Citation
Natural and Life Sciences Communications Vol.24 No.2 (2025)
Suggested Citation
Tangthikul S., Tachasuttirut K., Pongsiriwet S., Lekawanvijit S., Kitkumthorn N., Lapthanasupkul P., Iamaroon A. The Role of Human Papillomavirus in Oral Potentially Malignant Disorders and Cancer: A Review Literature. Natural and Life Sciences Communications Vol.24 No.2 (2025). doi:10.12982/NLSC.2025.028 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/109702
Title
The Role of Human Papillomavirus in Oral Potentially Malignant Disorders and Cancer: A Review Literature
Corresponding Author(s)
Other Contributor(s)
Abstract
Oral potentially malignant disorders (OPMDs) are conditions with abnormal changes of the oral mucosa that can potentially transform into oral squamous cell carcinoma (OSCC). Due to a rather high detection rate of human papillomavirus (HPV) in head and neck cancer particularly oropharyngeal carcinoma, HPV has been postulated as a plausible cause of OPMDs and OSCC development. A considerable number of studies have shown HPV can be detected in OSCC and OPMDs including oral leukoplakia (OL) and oral lichen planus (OLP). The detection rate nevertheless varies depending on the study design, data collection, and detection method. One of the most common methods for HPV detection is a polymerase chain reaction (PCR) analysis of E6 gene. However, the detection of the E6 gene may only reflect a bystander effect where HPV could exist in human tissues without host’s genomic integration. Genomic integration of HPV could be detected by various means including analyses of mRNA or protein expression in tissues of interest or detection of E2 gene since recent data have shown that E2 gene is disrupted upon genomic integration of the virus. In this review, we elaborated the nature of OPMDs and OSCC and emphasize on HPV infection and integration in OPMDs since detection of HPV at the early stages of oral cancer development may lead to alternative preventive and treatment measures for patients.