Inflammatory and homeostatic roles of eosinophil subpopulations in chronic rhinosinusitis with nasal polyp pathogenesis
2
Issued Date
2025-01-01
Resource Type
eISSN
16643224
Scopus ID
2-s2.0-105003689308
Journal Title
Frontiers in Immunology
Volume
16
Rights Holder(s)
SCOPUS
Bibliographic Citation
Frontiers in Immunology Vol.16 (2025)
Suggested Citation
Simmalee K., Lumjiaktase P., Kawamatawong T., Guemari A., Dormoy V., Vitte J. Inflammatory and homeostatic roles of eosinophil subpopulations in chronic rhinosinusitis with nasal polyp pathogenesis. Frontiers in Immunology Vol.16 (2025). doi:10.3389/fimmu.2025.1568541 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/109995
Title
Inflammatory and homeostatic roles of eosinophil subpopulations in chronic rhinosinusitis with nasal polyp pathogenesis
Corresponding Author(s)
Other Contributor(s)
Abstract
Chronic rhinosinusitis (CRS) with nasal polyps (CRSwNP) mainly expresses type-2 endotype, featuring eosinophils as a main player in the inflammatory process. Prolonged eosinophilia in the tissues of asthma and CRSwNP patients has been associated with structural changes, leading to fixed airflow obstruction in asthma and nasal polyposis in CRSwNP. This suggests that eosinophils may belong to different subgroups playing distinct roles in pathogenesis. Recent studies highlight the roles of inflammatory eosinophils (iEOS) in driving inflammation and tissue damage, whereas tissue-resident eosinophils (rEOS) maintain homeostasis and tissue repair in the airway. Therefore, understanding both roles of eosinophil subpopulations is crucial for better CRSwNP management, including enhancing the diagnosis accuracy, predicting recurrence, and optimizing treatment strategies.