Association Between Plasma Homocysteine, Folate, Vitamin B12 Levels, and Metabolic Dysfunction Indices in Elderly with Arterial Stiffness
Issued Date
2025-05-01
Resource Type
eISSN
20770383
Scopus ID
2-s2.0-105004917599
Journal Title
Journal of Clinical Medicine
Volume
14
Issue
9
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SCOPUS
Bibliographic Citation
Journal of Clinical Medicine Vol.14 No.9 (2025)
Suggested Citation
Sirivarasai J., Shantavasinkul P.C., Thitiwiwatkul M., Monsuwan W., Panpunuan P., Sritara P. Association Between Plasma Homocysteine, Folate, Vitamin B12 Levels, and Metabolic Dysfunction Indices in Elderly with Arterial Stiffness. Journal of Clinical Medicine Vol.14 No.9 (2025). doi:10.3390/jcm14092998 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/110239
Title
Association Between Plasma Homocysteine, Folate, Vitamin B12 Levels, and Metabolic Dysfunction Indices in Elderly with Arterial Stiffness
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Abstract
Background/Objectives: Arterial stiffness is a prevalent age-related condition that can significantly increase the risk of cardiovascular disease and mortality in older adults. Understanding the factors that contribute to vascular health, including metabolic dysfunction and hyperhomocysteinemia, alongside vitamin B status, is essential for developing effective interventions. This study aimed to explore the relationship between plasma levels of homocysteine, folate, and vitamin B12, as well as various indices of metabolic dysfunction, in elderly individuals with arterial stiffness. Methods: We conducted a cross-sectional analysis involving 884 participants aged 65 and older, assessing arterial stiffness using the cardio/ankle vascular index method. Additionally, we collected fasting blood samples to evaluate plasma homocysteine, folate, vitamin B12 levels, and other relevant biochemical markers. Results: Higher plasma homocysteine levels are significantly correlated with elevated CAVI scores and increased indices of metabolic dysfunction (p < 0.05). Furthermore, a multivariate logistic regression analysis demonstrated that elevated plasma homocysteine levels, along with higher levels of lipid accumulation product (LAP), triglyceride/glucose index (TyG), and visceral adiposity index (VAI), are associated with increased arterial stiffness. Conclusions: These findings suggest that monitoring and optimizing homocysteine, folate, and vitamin B12 levels may be beneficial for preventing or managing arterial stiffness and related metabolic disorders in the elderly population.