Functional Profiling of Antimicrobial Resistance in Rabbit Gut Microbiome
3
Issued Date
2025-06-01
Resource Type
eISSN
28139054
Scopus ID
2-s2.0-105008931434
Journal Title
Acta Microbiologica Hellenica Switzerland
Volume
70
Issue
2
Rights Holder(s)
SCOPUS
Bibliographic Citation
Acta Microbiologica Hellenica Switzerland Vol.70 No.2 (2025)
Suggested Citation
Chamtim P., Raethong N., Thananusak R. Functional Profiling of Antimicrobial Resistance in Rabbit Gut Microbiome. Acta Microbiologica Hellenica Switzerland Vol.70 No.2 (2025). doi:10.3390/amh70020021 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/111028
Title
Functional Profiling of Antimicrobial Resistance in Rabbit Gut Microbiome
Author(s)
Author's Affiliation
Corresponding Author(s)
Other Contributor(s)
Abstract
Antimicrobial resistance (AMR) is a growing concern in laboratory animals, where antibiotic use can disrupt the gut microbiome and promote resistant strains. Rabbits, commonly used in biomedical research, are particularly susceptible to gut dysbiosis, increasing the risk of infection and subsequent antibiotic use. This study used 16S rRNA amplicon sequencing and PICRUSt2 to predict resistance-related functions in rabbits under standard laboratory conditions. Among 2427 amplicon sequence variants, 42 functional classes were identified, with AMR comprising 1.55% of the predicted functions, including beta-lactam, vancomycin, and cationic antimicrobial peptide resistance. These AMR functions were associated with commensal genera such as Bacteroides and Ruminococcus, while no associations were observed with pathogens such as Escherichia or Salmonella. The study provides functional evidence of intrinsic AMR in the rabbit gut microbiome and underscores the importance of antimicrobial stewardship in laboratory animal research.