Publication: Treatment of giardiasis in children with quinacrine, metronidazole, tinidazole and ornidazole
Issued Date
1980-12-01
Resource Type
ISSN
00383619
Other identifier(s)
2-s2.0-0019200628
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Mahidol University
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SCOPUS
Bibliographic Citation
Southeast Asian Journal of Tropical Medicine and Public Health. Vol.11, No.2 (1980), 280-284
Suggested Citation
A. Sabchareon, T. Chongsuphajaisiddhi, P. Attanath Treatment of giardiasis in children with quinacrine, metronidazole, tinidazole and ornidazole. Southeast Asian Journal of Tropical Medicine and Public Health. Vol.11, No.2 (1980), 280-284. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/11126
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Title
Treatment of giardiasis in children with quinacrine, metronidazole, tinidazole and ornidazole
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Abstract
One hundred and twenty four children with symptomatic and parasitologically confirmed giardiasis were treated in a comparative trial. The dosage of antigiardia drug was adjusted to the body surface area of the patients from the adult basic dosage of 100 mg of quinacrine t.i.d. for 5 days, 200 mg of metronidazole t.i.d. for 7 days, 2 gm of metronidazole once, 2 gm of tinidazole once or 2 gm of ornidazole once. They were hospitalized for follow-up for 30 days. The parasitological follow-up consisted of daily examination of stool specimens. Reinfections were unlikely. The rates of success were: a 5-day course of quinacrine cured all 20 patients; a 7-day course of metronidazole, 12 of 20; metronidazole, single dose, 11 of 21; tinidazole, single dose, 18 of 21; ornidazole, single dose, 21 of 22; placebo, none of 20. After a single dose, 5 patients had transient elevation of transaminases: one patient each in the metronidazole and tinidazole group and 3 patients in the ornidazole group. A 5-day course of quinacrine gave excellent results but the drug is not widely marketed. Ornidazole or tinidazole were more effective. Both of them were recommended as a drug of choice as single dose therapy; however transient increase of transaminases may occur in some cases.