Immune-related adverse events associated with cancer immunotherapy
3
Issued Date
2025-08-08
Resource Type
ISSN
26666359
eISSN
26666340
Scopus ID
2-s2.0-105012526359
Journal Title
Med
Volume
6
Issue
8
Rights Holder(s)
SCOPUS
Bibliographic Citation
Med Vol.6 No.8 (2025)
Suggested Citation
Kungwankiattichai S., Desai A., Koppinger S., Maziarz R.T. Immune-related adverse events associated with cancer immunotherapy. Med Vol.6 No.8 (2025). doi:10.1016/j.medj.2025.100800 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/111670
Title
Immune-related adverse events associated with cancer immunotherapy
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Author's Affiliation
Corresponding Author(s)
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Abstract
Immunotherapy has become central to cancer care, whether in combination with traditional chemotherapy, as adjuvant therapy, or as primary therapy, and has been demonstrated to be central to treatment of newly diagnosed or relapsed disease in multiple randomized control trials. Antibody-based immunotherapy initiated the treatment revolution, but now immune effector cellular therapy is rapidly emerging and expanding its indications. Efficacy determinations have led to multiple international regulatory approvals, but unique significant toxicities have also been identified. It remains critical to understand risk factors that predict for adverse events that are encountered after administration of cancer immunotherapy. Similarly, identification of patient-related factors that enhance or diminish therapeutic efficacy, independent of the underlying malignancy, is critical for balancing the benefit and risk of immunotherapy. This review addresses the multiple new cellular therapy initiatives and addresses the importance of appropriate patient selection that will ultimately maximize the treatment benefit.