Dose-response relationship of cadmium and pancreatic cancer risk: a meta-analysis
Issued Date
2025-10-17
Resource Type
eISSN
14707926
Scopus ID
2-s2.0-105019265974
Pubmed ID
40962531
Journal Title
Occupational and Environmental Medicine
Volume
82
Issue
8
Start Page
407
End Page
414
Rights Holder(s)
SCOPUS
Bibliographic Citation
Occupational and Environmental Medicine Vol.82 No.8 (2025) , 407-414
Suggested Citation
Lee F.J., Inchai H., Lin J.T., Koh D., Lin R.T. Dose-response relationship of cadmium and pancreatic cancer risk: a meta-analysis. Occupational and Environmental Medicine Vol.82 No.8 (2025) , 407-414. 414. doi:10.1136/oemed-2025-110163 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/112802
Title
Dose-response relationship of cadmium and pancreatic cancer risk: a meta-analysis
Corresponding Author(s)
Other Contributor(s)
Abstract
Cadmium (Cd), a group 1 carcinogen, is linked to the development of pancreatic cancer. Not well-defined is the dose-response relationship between Cd and cancer development.This study investigated the relationship between Cd exposure and the risk of pancreatic cancer through a meta-analysis focusing on pooled relative risk (RR), biomarker comparisons and dose-response relationships.This meta-analysis adhered to PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines and applied the PECO (population, exposure, comparator and outcomes) framework. Systematic searches of key databases, including PubMed, Cochrane Library, Web of Science, EMBASE, ScienceDirect and ProQuest, were carried out without language restrictions. Studies that met the predefined PECO criteria were chosen, extracting data on effect estimates such as HRs, ORs, RRs and Cd biomarker concentrations. Analyses involved pooled RRs, standardised mean differences for biomarker comparisons and dose-response relationships, using random-effects meta-analysis and meta-regression. Statistical procedures were performed on R V.4.3.0.Cd exposure was significantly associated with an increased risk of pancreatic cancer, with a pooled RR of 1.42 (95% CI=1.16 to 1.73). Subgroup analyses confirmed this association in both occupationally and non-occupationally exposed individuals. Dose-response analyses further revealed that higher Cd biomarker levels correlated with greater pancreatic cancer risk (lnRR coefficient=0.610, p=0.035).Cd exposure is associated with an increased risk of pancreatic cancer, with a dose-response relationship and elevated biomarker levels in cases. Cd exposure is a modifiable risk factor for pancreatic cancer, meriting further investigation.