Pharmacologic Treatment of Kleine–Levin Syndrome: A Case Report and Comprehensive Review of Therapeutic Options
1
Issued Date
2026-03-01
Resource Type
eISSN
2574173X
Scopus ID
2-s2.0-105026587083
Pubmed ID
41491632
Journal Title
Neuropsychopharmacology Reports
Volume
46
Issue
1
Rights Holder(s)
SCOPUS
Bibliographic Citation
Neuropsychopharmacology Reports Vol.46 No.1 (2026)
Suggested Citation
Thawongit S., Siripornpanich V., Thampratankul L. Pharmacologic Treatment of Kleine–Levin Syndrome: A Case Report and Comprehensive Review of Therapeutic Options. Neuropsychopharmacology Reports Vol.46 No.1 (2026). doi:10.1002/npr2.70087 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/114534
Title
Pharmacologic Treatment of Kleine–Levin Syndrome: A Case Report and Comprehensive Review of Therapeutic Options
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Corresponding Author(s)
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Abstract
Kleine–Levin syndrome (KLS) is a rare disorder with limited literature on treatment options and efficacy, especially in adolescents. We report a 12-year-old patient with KLS who had a favorable response to clarithromycin therapy. In this unique case of KLS, both central hypopneas and a novel manifestation of REM sleep without atonia (RSWA) emerged during the episode and resolved with clarithromycin, suggesting a modulatory role on brainstem sleep networks and a possible neurophysiologic effect of clarithromycin therapy. However, reactions to pharmacologic treatment in individual KLS cases remain highly variable. Therefore, we compiled and summarized the available evidence to assist clinicians in evaluating potential therapeutic options.