Collagen cross-linking and antibacterial enhancement in dental adhesives via lignin and lignin-capped silver nanoparticles fillers
1
Issued Date
2026-01-01
Resource Type
ISSN
02874547
eISSN
18811361
Scopus ID
2-s2.0-105028357492
Journal Title
Dental Materials Journal
Volume
45
Issue
1
Start Page
19
End Page
28
Rights Holder(s)
SCOPUS
Bibliographic Citation
Dental Materials Journal Vol.45 No.1 (2026) , 19-28
Suggested Citation
Koolthi T., Maimansomsuk S., Matphang S., Teanchai C., Srinoi P., Waramit S., Lueangjaroenkit P., Akkarachaneeyakorn K. Collagen cross-linking and antibacterial enhancement in dental adhesives via lignin and lignin-capped silver nanoparticles fillers. Dental Materials Journal Vol.45 No.1 (2026) , 19-28. 28. doi:10.4012/dmj.2025-133 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/114592
Title
Collagen cross-linking and antibacterial enhancement in dental adhesives via lignin and lignin-capped silver nanoparticles fillers
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Corresponding Author(s)
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Abstract
The longevity of dental restorations is highly dependent on the durability of the resin-dentin interface, where collagen degradation and bacterial infiltration remain key challenges. Lignin, a natural and sustainable polymer, offers antioxidant, cross-linking, and antimicrobial potential, and its combination with silver nanoparticles (AgNPs) could further enhance antibacterial efficacy. This study aimed to investigate the use of lignin and lignin-capped AgNPs (lignin/AgNPs) as bio-based fillers in dental adhesives to improve collagen stability and antibacterial performance. Incorporating 0.5 wt% lignin and 0.5 wt% lignin/AgNPs into dental adhesives significantly improved bond strength, increasing from 15.36 MPa to 22.87 MPa and 27.54 MPa, respectively. FTIR analysis confirmed improved collagen cross-linking. While lignin alone provided limited antibacterial effects, lignin/AgNPs achieved strong activity against Streptococcus mutans. Importantly, both adhesives maintained bond strength after 6-month aging and exhibited no cytotoxicity at clinically relevant concentrations. These findings support their application in the development of advanced dental materials.