Publication: Poor diagnostic accuracy of commercial antibody-based assays for the diagnosis of acute Chikungunya infection
Issued Date
2011-10-01
Resource Type
ISSN
1556679X
15566811
15566811
Other identifier(s)
2-s2.0-80053447095
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Mahidol University
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SCOPUS
Bibliographic Citation
Clinical and Vaccine Immunology. Vol.18, No.10 (2011), 1773-1775
Suggested Citation
Stuart D. Blacksell, Ampai Tanganuchitcharnchai, Richard G. Jarman, Robert V. Gibbons, Daniel H. Paris, Mark S. Bailey, Nicholas P J Day, Ranjan Premaratna, David G. Lalloo, H. Janaka De Silva Poor diagnostic accuracy of commercial antibody-based assays for the diagnosis of acute Chikungunya infection. Clinical and Vaccine Immunology. Vol.18, No.10 (2011), 1773-1775. doi:10.1128/CVI.05288-11 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/11465
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Title
Poor diagnostic accuracy of commercial antibody-based assays for the diagnosis of acute Chikungunya infection
Abstract
A Sri Lankan fever cohort (n = 292 patients; 17.8% prevalence) was used to assess two standard diagnostic Chikungunya IgM tests. The immunochromatographic test (ICT) acute sample sensitivity (SN) was 1.9 to 3.9%, and specificity (SP) was 92.5 to 95.0%. The enzyme-linked immunosorbent assay (ELISA) gave an acute sample SN of 3.9% and an SP of 92.5% and a convalescent sample SN of 84% and an SP of 91%. These assays are not suitable for the acute diagnosis of Chikungunya virus infection. Copyright © 2011, American Society for Microbiology. All Rights Reserved.