Publication: HMGB1 as a therapeutic target in spinal cord injury: A hypothesis for novel therapy development (Review)
No. of Pages/File Size
Experimental and Therapeutic Medicine. Vol.2, No.5 (2011), 767-770
Kiyoshi Kikuchi, Hisaaki Uchikado, Naoki Miura, Yoko Morimoto, Takashi Ito, Salunya Tancharoen, Kei Miyata, Rokudai Sakamoto, Chiemi Kikuchi, Narumi Iida, Naoto Shiomi, Terukazu Kuramoto, Naohisa Miyagi, Ko Ichi Kawahara (2011). HMGB1 as a therapeutic target in spinal cord injury: A hypothesis for novel therapy development (Review). Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/11484.
HMGB1 as a therapeutic target in spinal cord injury: A hypothesis for novel therapy development (Review)
Historically, clinical outcomes following spinal cord injury (SCI) have been dismal. Severe SCI leads to devastating neurological deficits, and there is no treatment available that restores the injury-induced loss of function to a degree that an independent life can be guaranteed. To address all the issues associated with SCI, a multidisciplinary approach is required, as it is unlikely that a single approach, such as surgical intervention, pharmacotherapy or cellular transplantation, will suffice. High mobility group box 1 (HMGB1) is an inflammatory cytokine. Various studies have shown that HMGB1 plays a critical role in SCI and that inhibition of HMGB1 release may be a novel therapeutic target for SCI and may support spinal cord repair. In addition, HMGB1 has been associated with graft rejection in the early phase. Therefore, HMGB1 may be a promising therapeutic target for SCI transplant.