AsPNA Clinical Practice Guidelines for the management of infection-related glomerulonephritis
Issued Date
2026-01-01
Resource Type
ISSN
0931041X
eISSN
1432198X
Scopus ID
2-s2.0-105029435653
Pubmed ID
41627401
Journal Title
Pediatric Nephrology
Rights Holder(s)
SCOPUS
Bibliographic Citation
Pediatric Nephrology (2026)
Suggested Citation
Meena J., Sinha A., Krishnasamy S., Alba A.A., Aziz M.A., Begum A., Chan E.Y.h., Kari J.A., Pattaragarn A., Perera I., Shen Q., Singh G., Bagga A. AsPNA Clinical Practice Guidelines for the management of infection-related glomerulonephritis. Pediatric Nephrology (2026). doi:10.1007/s00467-026-07146-4 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/115027
Title
AsPNA Clinical Practice Guidelines for the management of infection-related glomerulonephritis
Author's Affiliation
Chinese University of Hong Kong
All India Institute of Medical Sciences, New Delhi
Siriraj Hospital
Jawaharlal Institute of Postgraduate Medical Education and Research
Children’s Hospital of Fudan University
King Abdulaziz University Hospital
Bangabandhu Sheikh Mujib Medical University
Indraprastha Apollo Hospitals
Sindh Institute of Urology and Transplantation
The Medical City
Sirimavo Bandaranayake Specialized Children’s Hospital
All India Institute of Medical Sciences, New Delhi
Siriraj Hospital
Jawaharlal Institute of Postgraduate Medical Education and Research
Children’s Hospital of Fudan University
King Abdulaziz University Hospital
Bangabandhu Sheikh Mujib Medical University
Indraprastha Apollo Hospitals
Sindh Institute of Urology and Transplantation
The Medical City
Sirimavo Bandaranayake Specialized Children’s Hospital
Corresponding Author(s)
Other Contributor(s)
Abstract
Infection-related glomerulonephritis (IRGN) is the leading cause of acute glomerulonephritis (GN) in children worldwide, particularly in low- and middle-income countries. To provide evidence-based care, the Glomerular Disease Workgroup of the Asian Pediatric Nephrology Association (AsPNA) convened a panel of experts to develop recommendations on diagnosis, evaluation and management of pediatric IRGN. Following a comprehensive literature search, available evidence was graded using the AAP-GRADE approach, and recommendations finalized through Delphi consensus. The panel recommends diagnosing acute GN in children presenting with hematuria and proteinuria, if accompanied with edema, oliguria, or hypertension. Postinfectious GN is suspected in patients with acute GN with recent streptococcal or staphylococcal infection and transient hypocomplementemia. The evaluation includes urinalysis, kidney function tests, serum albumin, complement C3, blood counts and kidney ultrasonography. Kidney biopsy is required for patients with atypical features, nephrotic syndrome, persistently low C3 beyond 12 weeks, and/or rapidly progressive GN. Therapy is chiefly supportive, including fluid and salt restriction in patients with edema or hypertension, diuretics for volume overload, and calcium channel blockers for stage 2 hypertension. Patients with significant edema, severe hypertension, or acute kidney injury require inpatient monitoring. Patients with staphylococcus-associated GN infective endocarditis associated GN and shunt nephritis require therapy with antibiotics. Immunosuppressive therapy is suggested in patients with crescentic IRGN or rapidly progressive course. All patients with IRGN, particularly those with crescentic GN or rapidly progressive GN, require long-term monitoring of serum creatinine, urinalysis and blood pressure. These guidelines intend to provide a structured, evidence-informed approach for the management of patients with IRGN.