An international survey on current practices of management of neonatal catheter-associated venous thromboembolism: communication from the ISTH SSC Subcommittee on Pediatric and Neonatal Thrombosis and Hemostasis
1
Issued Date
2026-01-01
Resource Type
ISSN
15387933
eISSN
15387836
Scopus ID
2-s2.0-105039964616
Pubmed ID
41887532
Journal Title
Journal of Thrombosis and Haemostasis
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Thrombosis and Haemostasis (2026)
Suggested Citation
Bhat R., Hulzebos C.V., Barg A., Beg K., Bhatt M., Chan A.K.C., Faustino E.V.S., Holzhauer S., Jones S., Knol R., Pelland-Marcotte M.C., Goldenberg N., Sirachainan N., van Ommen H. An international survey on current practices of management of neonatal catheter-associated venous thromboembolism: communication from the ISTH SSC Subcommittee on Pediatric and Neonatal Thrombosis and Hemostasis. Journal of Thrombosis and Haemostasis (2026). doi:10.1016/j.jtha.2026.02.028 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/117052
Title
An international survey on current practices of management of neonatal catheter-associated venous thromboembolism: communication from the ISTH SSC Subcommittee on Pediatric and Neonatal Thrombosis and Hemostasis
Author's Affiliation
University of Melbourne
Tel Aviv University
Yale School of Medicine
Charité – Universitätsmedizin Berlin
Northwestern University Feinberg School of Medicine
Erasmus MC
CHU de Québec-Université Laval
Erasmus MC Sophia Children’s Hospital
Faculty of Medicine Ramathibodi Hospital, Mahidol University
Johns Hopkins All Children's Hospital
Beatrix Kinderziekenhuis
McMaster Children's Hospital
Section of Hematology/Oncology at OU Health
Tel Aviv University
Yale School of Medicine
Charité – Universitätsmedizin Berlin
Northwestern University Feinberg School of Medicine
Erasmus MC
CHU de Québec-Université Laval
Erasmus MC Sophia Children’s Hospital
Faculty of Medicine Ramathibodi Hospital, Mahidol University
Johns Hopkins All Children's Hospital
Beatrix Kinderziekenhuis
McMaster Children's Hospital
Section of Hematology/Oncology at OU Health
Corresponding Author(s)
Other Contributor(s)
Abstract
Background The International Society on Thrombosis and Haemostasis Scientific and Standardization Committee on Pediatric/Neonatal Thrombosis and Haemostasis formed a multidisciplinary working group to assess current practices in the management of neonatal thrombosis, focusing on catheter-associated venous thromboembolism (CA-VTE) and to identify gaps in care. Objectives To determine which clinicians manage neonatal thrombosis and to characterize diagnostic and treatment approaches for neonatal CA-VTE. Methods An international cross-sectional survey was conducted using REDCap (version 14.5.7) from October 1, 2024 to December 31, 2024, following institutional review board approval. The survey was distributed through international professional societies to clinicians involved in neonatal thrombosis care. Neonates were defined as term and preterm infants from birth up to 44 weeks corrected gestational age. Descriptive statistics summarized demographics and responses to multiple-choice and Likert scale-type questions. Results A total of 135 clinicians participated, primarily neonatologists ( n = 59, 43.7%) and pediatric hematologists ( n = 55, 39.3%). Most had over 10 years of clinical experience ( n = 90, 66.7%). Neonatal thrombosis was primarily managed in level III/IV neonatal intensive care units with <5 cases per year ( n = 43, 31.9%). Treatment decisions were influenced by degree of occlusion ( n = 107, 79%), symptoms ( n = 105, 77.8%), thrombus location ( n = 96, 71.1%), and bleeding risk ( n = 98, 72.6%). Heparins were the most common anticoagulants used in both acute (93.3%) and subacute (82.8%) phases. Treatment duration varied widely, from <4 to >12 weeks. Management (expectant vs anticoagulation) depended on thrombus characteristics. Conclusion Our findings underscore significant variability in the management of neonatal CA-VTE and highlight opportunities for standardization. Enhanced awareness and international collaboration are essential to improving outcomes for this vulnerable population.