Biosafety and biosecurity for Burkholderia pseudomallei and Burkholderia mallei: evidence, gaps, and sustainable practice in endemic, low-resource settings
Issued Date
2026-06-01
Resource Type
ISSN
08938512
eISSN
10986618
Scopus ID
2-s2.0-105041948913
Pubmed ID
41810995
Journal Title
Clinical Microbiology Reviews
Volume
39
Issue
2
Rights Holder(s)
SCOPUS
Bibliographic Citation
Clinical Microbiology Reviews Vol.39 No.2 (2026)
Suggested Citation
Blacksell S.D., Le K.K., Dhawan S., Wuthiekanun V., Limmathurotsukul D., Dunachie S.J., Norton R., Meumann E., Currie B.J., Day N.P.J., Dance D.A.B. Biosafety and biosecurity for Burkholderia pseudomallei and Burkholderia mallei: evidence, gaps, and sustainable practice in endemic, low-resource settings. Clinical Microbiology Reviews Vol.39 No.2 (2026). doi:10.1128/cmr.00369-25 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/117468
Title
Biosafety and biosecurity for Burkholderia pseudomallei and Burkholderia mallei: evidence, gaps, and sustainable practice in endemic, low-resource settings
Corresponding Author(s)
Other Contributor(s)
Abstract
Burkholderia pseudomallei and Burkholderia mallei present significant biosafety challenges due to their high pathogenicity, environmental resilience, intrinsic antimicrobial resistance, and potential use as bioterrorism agents. This review examines key aspects of laboratory management and infection control for these organisms, focusing on inconsistencies in biosafety protocols and risk classifications across regions. We synthesize current evidence on biocontainment requirements, disinfection strategies, and personal protective equipment (PPE), with particular emphasis on sustainable practices for laboratories in low-resource settings. Although laboratory-acquired infections are rare, their potential severity underscores the importance of stringent safety measures. Critical gaps remain in our understanding of infectious dose, the effectiveness.