Publication: Dengue antibody in thai children from maternally transferred antibody to acquired infection
Issued Date
2011-01-01
Resource Type
ISSN
15320987
08913668
08913668
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2-s2.0-80052937140
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Mahidol University
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SCOPUS
Bibliographic Citation
Pediatric Infectious Disease Journal. Vol.30, No.10 (2011), 897-900
Suggested Citation
Krisana Pengsaa, Kriengsak Limkittikul, Sutee Yoksan, Pataporn Wisetsing, Arunee Sabchareon Dengue antibody in thai children from maternally transferred antibody to acquired infection. Pediatric Infectious Disease Journal. Vol.30, No.10 (2011), 897-900. doi:10.1097/INF.0b013e31821f07f6 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/12707
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Title
Dengue antibody in thai children from maternally transferred antibody to acquired infection
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Abstract
This prospective cohort study examined serotype-specific neutralizing serum antibodies to dengue in 55 maternal-newborn pairs, at 3, 6, 9, 12, 18, and 24 months, and again at 4 to 8 years of age. In all, 95% of the mothers had neutralizing antibody to at least one dengue serotype, and 92.7% of the maternally transferred antibody had disappeared in 12-month-old infants. In all, 31 infants had serologically confirmed dengue infection; 5 symptomatic and 29 inapparent infections were reported. The increasing trend of inapparent infections among the older age group warrants further study of the need for effective dengue vaccination beyond 2 years of age. Copyright © 2011 by Lippincott Williams & Wilkins.