General Pharmacology: Vascular System. Vol.8, No.4 (1978), 263-267
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C. Sadavongvivad, J. Satayavivad, V. Prachayasittikul, L. Mo-Suwun Modification of relative potencies of beta-adrenoceptor agonists by negative chronotropic agents in rat atrium. General Pharmacology: Vascular System. Vol.8, No.4 (1978), 263-267. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/13134
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Modification of relative potencies of beta-adrenoceptor agonists by negative chronotropic agents in rat atrium
Lowering temperature r420w9 =and the reduced maximal effects of all four common adrenoceptor agonists without any change in their potencies. Quinidine reduced their potencies slightly and lowered maximal effects only at high concentrations. Adenosine caused a large decrease in potency of isoprenaline but hardly affected that of phenylephrine. These andthe authors previous results indicate that some endogeneous negative chronotropic agents can alter relative potencies of the agonists as well as characteristics of blockers.
