Publication: Renal blood flow after bilateral ureteral ligation in the rat
1
Issued Date
1979-08-01
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ISSN
14322013
00316768
00316768
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2-s2.0-0018715938
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Mahidol University
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SCOPUS
Bibliographic Citation
Pflügers Archiv European Journal of Physiology. Vol.381, No.2 (1979), 165-169
Suggested Citation
Samaisukh Sophasan, Buarong Saraggananda Renal blood flow after bilateral ureteral ligation in the rat. Pflügers Archiv European Journal of Physiology. Vol.381, No.2 (1979), 165-169. doi:10.1007/BF00582348 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/13151
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Title
Renal blood flow after bilateral ureteral ligation in the rat
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Abstract
Renal blood flow (RBF) in rat was measured by using a noncannulating electromagnetic flowmeter. In the sham control rats, anesthetized with Inactin, RBF averaged 7 ml/min/g KW when arterial blood pressure was above 110 mm Hg. Auroregulation of RBF was observed when the arterial blood pressure was in the range of 110-150 mm Hg. Glomerular filtration rate (GFR), measured by polyfructosan clearance, averaged 1.08 ml/min/g KW. In experimental rats with 24 h of bilateral ureteral ligation (BUL), RBF averaged 38% of control value. During 1/2-3 h following release of the left ureteral occlusion, RBF increased to 60% of control value. The autoregulatory ability of the damaged kidney was reduced during BUL and did not improve after releasing occlusion. During the post-obstructive period arterial blood pressure remained stable. Thus, a high total renal vascular resistance was responsible for the depressed RBF. GFR in these rats averaged only 9% of control value. The reduction in RBF alone does not explain the drastic reduction in GFR in this model of renal failure. © 1979 Springer-Verlag.