Publication:
Immunofluorescent Staining of Platelet Suspensions and Detection of Antiplatelet Antibody in Patients with Idiopathic Thrombocytopenic Purpura

Issued Date

1979-01-01

Resource Type

Article

ISSN

14230410
00429007

DOI

10.1111/j.1423-0410.1979.tb04410.x

Other identifier(s)

2-s2.0-0018395517

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Vox Sanguinis. Vol.36, No.2 (1979), 115-120

Suggested Citation

Somnate Boonpucknavig, Oranut Vuttivirojana, Tanomsri Srichaikul Immunofluorescent Staining of Platelet Suspensions and Detection of Antiplatelet Antibody in Patients with Idiopathic Thrombocytopenic Purpura. Vox Sanguinis. Vol.36, No.2 (1979), 115-120. doi:10.1111/j.1423-0410.1979.tb04410.x Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/13281

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Title

Immunofluorescent Staining of Platelet Suspensions and Detection of Antiplatelet Antibody in Patients with Idiopathic Thrombocytopenic Purpura

Author(s)

Somnate Boonpucknavig
 Oranut Vuttivirojana
 Tanomsri Srichaikul

Other Contributor(s)

Faculty of Science
 Mahidol University

Abstract

Abstract. Direct immunofluorescent staining of 31 specimens of platelets obtained from 13 cases of idiopathic thrombocytopenic purpura (ITP) revealed positive staining on the surface of platelets for both immunoglobulins (Igs) and human β 1 C globulin in 9 specimens, for only Igs in 1 specimen and for human β 1 C alone in 5 specimens. The pattern of the positive immunofluorescent staining was granular. Indirect immunofluorescent staining of normal platelets in serum obtained from patients with ITP was positive for antiplatelet antibody in 9 out of 31 specimens. This suggests that platelets in patients with ITP may be damaged by an antiplatelet autoantibody acting directly on the platelet surface and/or by antigen antibody complexes binding via Fc IgG receptors on the surface of the platelets. © 1979 Blackwell Publishing Ltd

Keyword(s)

Medicine

Availability

URI

https://repository.li.mahidol.ac.th/handle/123456789/13281

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Scopus 1969-1990