Publication: Applications of cell-penetrating peptides for tumor targeting and future cancer therapies
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Issued Date
2012-07-12
Resource Type
ISSN
14248247
Other identifier(s)
2-s2.0-84866535298
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Mahidol University
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SCOPUS
Bibliographic Citation
Pharmaceuticals. Vol.5, No.9 (2012), 991-1007
Suggested Citation
Jakob Regberg, Artita Srimanee, Ülo Langel Applications of cell-penetrating peptides for tumor targeting and future cancer therapies. Pharmaceuticals. Vol.5, No.9 (2012), 991-1007. doi:10.3390/ph5090991 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/13666
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Title
Applications of cell-penetrating peptides for tumor targeting and future cancer therapies
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Abstract
Cell-penetrating peptides provide a highly promising strategy for intracellular drug delivery. One relevant clinical application of cell-penetrating peptides is cancer therapeutics. Peptide based delivery could increase the uptake of drugs in tumor cells and thereby increase the efficacy of the treatment, either of conventional small molecular drugs or oligonucleotide based therapeutics. This review is focused on the cancer applications of cell penetrating peptides as delivery systems; different aspects of drug loading, cargoes and delivery are discussed together with methods for targeted delivery, activatable cell-penetrating peptides and transducible agents coupled to cell-penetrating peptides. © 2012 by the authors; licensee MDPI, Basel, Switzerland.