Publication:
Novel roles of soxR, a transcriptional regulator from Xanthomonas campestris, in sensing redox-cycling drugs and regulating a protective gene that have overall implications for bacterial stress physiology and virulence on a host plant

Issued Date

2012-01-01

Resource Type

Article

ISSN

10985530
00219193

DOI

10.1128/JB.05603-11

Other identifier(s)

2-s2.0-84855891357

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Journal of Bacteriology. Vol.194, No.2 (2012), 209-217

Suggested Citation

Aekkapol Mahavihakanont, Nisanart Charoenlap, Poommaree Namchaiw, Warawan Eiamphungporn, Sorayut Chattrakarn, Paiboon Vattanaviboon, Skorn Mongkolsuk Novel roles of soxR, a transcriptional regulator from Xanthomonas campestris, in sensing redox-cycling drugs and regulating a protective gene that have overall implications for bacterial stress physiology and virulence on a host plant. Journal of Bacteriology. Vol.194, No.2 (2012), 209-217. doi:10.1128/JB.05603-11 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/13864

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Title

Novel roles of soxR, a transcriptional regulator from Xanthomonas campestris, in sensing redox-cycling drugs and regulating a protective gene that have overall implications for bacterial stress physiology and virulence on a host plant

Author(s)

Aekkapol Mahavihakanont
 Nisanart Charoenlap
 Poommaree Namchaiw
 Warawan Eiamphungporn
 Sorayut Chattrakarn
 Paiboon Vattanaviboon
 Skorn Mongkolsuk

Other Contributor(s)

Chulabhorn Research Institute
 Environmental Health
 Mahidol University
 Center of Excellence on Environmental Health

Abstract

In Xanthomonas campestris pv. campestris, SoxR likely functions as a sensor of redox-cycling drugs and as a transcriptional regulator. Oxidized SoxR binds directly to its target site and activates the expression of xcc0300, a gene that has protective roles against the toxicity of redox-cycling compounds. In addition, SoxR acts as a noninducible repressor of its own expression. X. campestris pv. campestris requires SoxR both for protection against redox-cycling drugs and for full virulence on a host plant. The X. campestris model of the gene regulation and physiological roles of SoxR represents a novel variant of existing bacterial SoxR models. © 2012, American Society for Microbiology.

Keyword(s)

Biochemistry, Genetics and Molecular Biology
 Immunology and Microbiology

Availability

URI

https://repository.li.mahidol.ac.th/handle/123456789/13864

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