Publication: Prevalence of drug resistance-associated gene mutations in plasmodium vivax in central china
1
Issued Date
2012-01-01
Resource Type
ISSN
17380006
00234001
00234001
Other identifier(s)
2-s2.0-84870851841
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Korean Journal of Parasitology. Vol.50, No.4 (2012), 379-384
Suggested Citation
Feng Lu, Bo Wang, Jun Cao, Jetsumon Sattabongkot, Huayun Zhou, Guoding Zhu, Kwonkee Kim, Qi Gao, Eun Taek Han Prevalence of drug resistance-associated gene mutations in plasmodium vivax in central china. Korean Journal of Parasitology. Vol.50, No.4 (2012), 379-384. doi:10.3347/kjp.2012.50.4.379 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/14365
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Prevalence of drug resistance-associated gene mutations in plasmodium vivax in central china
Abstract
Resistance of Plasmodium spp. to anti-malarial drugs is the primary obstacle in the fght against malaria, and molecular markers for the drug resistance have been applied as an adjunct in the surveillance of the resistance. In this study, we investigated the prevalence of mutations in pvmdr1, pvcrt-o, pvdhfr, and pvdhps genes in temperate-zone P. vivax parasites from central China. A total of 26 isolates were selected, including 8 which were previously shown to have a lower susceptibility to chloroquine in vitro. For pvmdr1, pvcrt-o, and pvdhps genes, no resistance-conferring mutations were discovered. However, a highly prevalent (69.2%), single-point mutation (S117N) was found in pvdhfr gene. In addi- tion, tandem repeat polymorphisms existed in pvdhfr and pvdhps genes, which warranted further studies in relation to the parasite resistance to antifolate drugs. The study further suggests that P. vivax populations in central China may still be relatively susceptible to chloroquine and sulfadoxine-pyrimethamine. © 2012, Korean Society for Parasitology and Tropical Medicine.