Publication:
Adult-onset immunodeficiency in Thailand and Taiwan

Submitted Date
Received Date
Accepted Date
Issued Date
2012-08-23
Copyright Date
Announcement No.
Application No.
Patent No.
Valid Date
Resource Type
Article
Edition
Resource Version
Language
File Type
No. of Pages/File Size
ISBN
ISSN
15334406
00284793
eISSN
DOI
10.1056/NEJMoa1111160
Scopus ID
WOS ID
Pubmed ID
arXiv ID
Call No.
Other identifier(s)
2-s2.0-84865300679
Journal Title
Volume
Issue
item.page.oaire.edition
Start Page
End Page
Access Rights
Access Status
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Physical Location
Bibliographic Citation
New England Journal of Medicine. Vol.367, No.8 (2012), 725-734
Citation
Sarah K. Browne, Peter D. Burbelo, Ploenchan Chetchotisakd, Yupin Suputtamongkol, Sasisopin Kiertiburanakul, Pamela A. Shaw, Jennifer L. Kirk, Kamonwan Jutivorakool, Rifat Zaman, Li Ding, Amy P. Hsu, Smita Y. Patel, Kenneth N. Olivier, Viraphong Lulitanond, Piroon Mootsikapun, Siriluck Anunnatsiri, Nasikarn Angkasekwinai, Boonmee Sathapatayavongs, Po Ren Hsueh, Chi Chang Shieh, Margaret R. Brown, Wanna Thongnoppakhun, Reginald Claypool, Elizabeth P. Sampaio, Charin Thepthai, Duangdao Waywa, Camilla Dacombe, Yona Reizes, Adrian M. Zelazny, Paul Saleeb, Lindsey B. Rosen, Allen Mo, Michael Iadarola, Steven M. Holland (2012). Adult-onset immunodeficiency in Thailand and Taiwan. Retrieved from: https://hdl.handle.net/20.500.14594/14687.
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Adult-onset immunodeficiency in Thailand and Taiwan
Alternative Title(s)
Author(s)
Sarah K. Browne
 Peter D. Burbelo
 Ploenchan Chetchotisakd
 Yupin Suputtamongkol
 Sasisopin Kiertiburanakul
 Pamela A. Shaw
 Jennifer L. Kirk
 Kamonwan Jutivorakool
 Rifat Zaman
 Li Ding
 Amy P. Hsu
 Smita Y. Patel
 Kenneth N. Olivier
 Viraphong Lulitanond
 Piroon Mootsikapun
 Siriluck Anunnatsiri
 Nasikarn Angkasekwinai
 Boonmee Sathapatayavongs
 Po Ren Hsueh
 Chi Chang Shieh
 Margaret R. Brown
 Wanna Thongnoppakhun
 Reginald Claypool
 Elizabeth P. Sampaio
 Charin Thepthai
 Duangdao Waywa
 Camilla Dacombe
 Yona Reizes
 Adrian M. Zelazny
 Paul Saleeb
 Lindsey B. Rosen
 Allen Mo
 Michael Iadarola
 Steven M. Holland
Author's Affiliation
Author's E-mail
Editor(s)
Editor's Affiliation
Corresponding Author(s)
Creator(s)
Compiler
Advisor(s)
Illustrator(s)
Applicant(s)
Inventor(s)
Issuer
Assignee
Other Contributor(s)
National Institute of Allergy and Infectious Diseases
 National Institute of Dental and Craniofacial Research
 National Institutes of Health, Bethesda
 Systex
 Khon Kaen University
 Mahidol University
 Chulalongkorn University
 University of Oxford
 National Taiwan University
 National Cheng Kung University
 Fundacao Oswaldo Cruz
 Colgate University
Series
Has Part
Abstract
BACKGROUND: Autoantibodies against interferon-γ are associated with severe disseminated opportunistic infection, but their importance and prevalence are unknown. METHODS: We enrolled 203 persons from sites in Thailand and Taiwan in five groups: 52 patients with disseminated, rapidly or slowly growing, nontuberculous mycobacterial infection (group 1); 45 patients with another opportunistic infection, with or without nontuberculous mycobacterial infection (group 2); 9 patients with disseminated tuberculosis (group 3); 49 patients with pulmonary tuberculosis (group 4); and 48 healthy controls (group 5). Clinical histories were recorded, and blood specimens were obtained. RESULTS: Patients in groups 1 and 2 had CD4+ T-lymphocyte counts that were similar to those in patients in groups 4 and 5, and they were not infected with the human immunodeficiency virus (HIV). Washed cells obtained from patients in groups 1 and 2 had intact cytokine production and a response to cytokine stimulation. In contrast, plasma obtained from these patients inhibited the activity of interferon-γ in normal cells. High-titer anti-interferon-γ autoantibodies were detected in 81% of patients in group 1, 96% of patients in group 2, 11% of patients in group 3, 2% of patients in group 4, and 2% of controls (group 5). Forty other anticytokine autoantibodies were assayed. One patient with cryptococcal meningitis had autoantibodies only against granulocyte-macrophage colony-stimulating factor. No other anticytokine autoantibodies or genetic defects correlated with infections. There was no familial clustering. CONCLUSIONS: Neutralizing anti-interferon-γ autoantibodies were detected in 88% of Asian adults with multiple opportunistic infections and were associated with an adult-onset immunodeficiency akin to that of advanced HIV infection. (Funded by the National Institute of Allergy and Infectious Diseases and the National Institute of Dental and Craniofacial Research; ClinicalTrials.gov number, NCT00814827.) Copyright © 2012 Massachusetts Medical Society.
Table of contents
Description
Sponsorship
Degree Name
Degree Level
Degree Department
Degree Discipline
Degree Grantor(s)
Classification
DDC
MESH
Subject(s)
Keyword(s)
Medicine
View online Resources
URI
https://hdl.handle.net/20.500.14594/14687
Collections
Scopus 2011-2015