Publication: Lipodystrophy and reversal of facial lipoatrophy in perinatally HIV-infected children and adolescents after discontinuation of stavudine
Issued Date
2012-07-01
Resource Type
ISSN
09564624
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2-s2.0-84864478578
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Mahidol University
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SCOPUS
Bibliographic Citation
International Journal of STD and AIDS. Vol.23, No.7 (2012), 497-501
Suggested Citation
N. Sawawiboon, O. Wittawatmongkol, W. Phongsamart, W. Prasitsuebsai, K. Lapphra, K. Chokephaibulkit Lipodystrophy and reversal of facial lipoatrophy in perinatally HIV-infected children and adolescents after discontinuation of stavudine. International Journal of STD and AIDS. Vol.23, No.7 (2012), 497-501. doi:10.1258/ijsa.2011.011348 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/14731
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Title
Lipodystrophy and reversal of facial lipoatrophy in perinatally HIV-infected children and adolescents after discontinuation of stavudine
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Abstract
Lipodystrophy (LD) was evaluated in 205 children receiving antiretroviral therapy by a single investigator: 51 (24.9%) had LD; 46 peripheral lipoatrophy, three central lipohypertrophy and two combined type. All cases of peripheral and combined LD also had facial lipoatrophy. Serial photographs were provided by the families to confirm the severity of facial lipoatrophy. Forty-six (95.8%) children with peripheral or combined LD, and 75 (48.7%) without LD were exposed to stavudine (d4T) for a median duration of 45.9 versus 26.4 months (P 1/4 0.005). In multivariate analysis, exposure to d4T for more than three months was the only factor associated with peripheral or combined LD (P, 0.001). Noticeable improvement of facial lipoatrophy was found in 11/48 (22.9%) children after a mean duration of 45.6 months following d4T discontinuation, mostly occurring during early adolescence.