Publication: Functionalized (poly(ε-caprolactone))<inf>2</inf>-poly(ethylene glycol) nanoparticles with grafting nicotinic acid as drug carriers
Issued Date
2012-02-28
Resource Type
ISSN
18733476
03785173
03785173
Other identifier(s)
2-s2.0-84856525437
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
International Journal of Pharmaceutics. Vol.423, No.2 (2012), 562-570
Suggested Citation
Jiraphong Suksiriworapong, Kittisak Sripha, Jörg Kreuter, Varaporn Buraphacheep Junyaprasert Functionalized (poly(ε-caprolactone))<inf>2</inf>-poly(ethylene glycol) nanoparticles with grafting nicotinic acid as drug carriers. International Journal of Pharmaceutics. Vol.423, No.2 (2012), 562-570. doi:10.1016/j.ijpharm.2011.11.033 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/15174
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Functionalized (poly(ε-caprolactone))<inf>2</inf>-poly(ethylene glycol) nanoparticles with grafting nicotinic acid as drug carriers
Other Contributor(s)
Abstract
Nicotinic acid was grafted on (poly(ε-caprolactone)) 2 -poly(ethylene glycol) copolymers that were used for the preparation of nanoparticles with the objectives to monitor particle size and to optimize the drug loading capacity as well as the release profile of the particles. Increasing amounts of grafting nicotinic acid increased the particle size as a result of an enhanced hydrophobicity of the copolymer. Ibuprofen and indomethacin with two different molecular characteristics were selected as model drugs to be bound to the nanoparticles. The presence of grafting nicotinic acid enhanced the loading capacity for both drugs compared to the nanoparticles without nicotinic acid. However, no correlation between amount of grafting nicotinic acid and loading capacity was observed. The release characteristic of both d rugs was fitted to the Higuchi model indicating Fickian diffusion. The release characteristic of indomethacin mainly depended on the crystalline property of the copolymer whereas that of ibuprofen was additionally influenced by the hydrogen bonding between drug and grafted copolymer. © 2011 Elsevier B.V. All rights reserved.