Publication: A major genome region underlying artemisinin resistance in malaria
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2012-04-06
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10959203
00368075
00368075
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2-s2.0-84859506329
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Mahidol University
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Science. Vol.335, No.6077 (2012), 79-82
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Ian H. Cheeseman, Becky A. Miller, Shalini Nair, Standwell Nkhoma, Asako Tan, John C. Tan, Salma Al Saai, Aung Pyae Phyo, Carit Ler Moo, Khin Maung Lwin, Rose McGready, Elizabeth Ashley, Mallika Imwong, Kasia Stepniewska, Poravuth Yi, Arjen M. Dondorp, Mayfong Mayxay, Paul N. Newton, Nicholas J. White, François Nosten, Michael T. Ferdig, Timothy J.C. Anderson (2012). A major genome region underlying artemisinin resistance in malaria. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/15247.
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A major genome region underlying artemisinin resistance in malaria
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Author(s)
Ian H. Cheeseman
Becky A. Miller
Shalini Nair
Standwell Nkhoma
Asako Tan
John C. Tan
Salma Al Saai
Aung Pyae Phyo
Carit Ler Moo
Khin Maung Lwin
Rose McGready
Elizabeth Ashley
Mallika Imwong
Kasia Stepniewska
Poravuth Yi
Arjen M. Dondorp
Mayfong Mayxay
Paul N. Newton
Nicholas J. White
François Nosten
Michael T. Ferdig
Timothy J.C. Anderson
Becky A. Miller
Shalini Nair
Standwell Nkhoma
Asako Tan
John C. Tan
Salma Al Saai
Aung Pyae Phyo
Carit Ler Moo
Khin Maung Lwin
Rose McGready
Elizabeth Ashley
Mallika Imwong
Kasia Stepniewska
Poravuth Yi
Arjen M. Dondorp
Mayfong Mayxay
Paul N. Newton
Nicholas J. White
François Nosten
Michael T. Ferdig
Timothy J.C. Anderson
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Abstract
Evolving resistance to artemisinin-based compounds threatens to derail attempts to control malaria. Resistance has been confirmed in western Cambodia and has recently emerged in western Thailand, but is absent from neighboring Laos. Artemisinin resistance results in reduced parasite clearance rates (CRs) after treatment. We used a two-phase strategy to identify genome region(s) underlying this ongoing selective event. Geographical differentiation and haplotype structure at 6969 polymorphic single-nucleotide polymorphisms (SNPs) in 91 parasites from Cambodia, Thailand, and Laos identified 33 genome regions under strong selection. We screened SNPs and microsatellites within these regions in 715 parasites from Thailand, identifying a selective sweep on chromosome 13 that shows strong association (P = 10 -6 to 10 -12 ) with slow CRs, illustrating the efficacy of targeted association for identifying the genetic basis of adaptive traits.