Publication: Adherence of human eosinophils to infective filariform larvae of Necator americanus in vitro.
1
Issued Date
1987-03-01
Resource Type
ISSN
01251562
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2-s2.0-0023301015
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Mahidol University
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SCOPUS
Bibliographic Citation
The Southeast Asian journal of tropical medicine and public health. Vol.18, No.1 (1987), 66-72
Suggested Citation
V. Desakorn, P. Suntharasamai, S. Pukrittayakamee, S. Migasena, D. Bunnag Adherence of human eosinophils to infective filariform larvae of Necator americanus in vitro.. The Southeast Asian journal of tropical medicine and public health. Vol.18, No.1 (1987), 66-72. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/15429
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Title
Adherence of human eosinophils to infective filariform larvae of Necator americanus in vitro.
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Abstract
Eosinophilia is common in hookworm infection but the interaction between eosinophils and the larval stage of the parasite is poorly understood. The present study was conducted to test the ability of the eosinophils to adhere to infective filariform larvae of Necator americanus in vitro. Adherence of eosinophils to the larvae was found to be serum dependent. Antibody facilitated eosinophil adherence but this was maximal in the presence of complement. The adherence was greatly diminished by EGTA treated normal human serum (NHS) and was completely abolished when NHS was treated with either EDTA or heat-inactivation, suggesting that the process can be facilitated through complement activation via the alternative pathway. As with other nematodes, the surface of hookworm larvae appeared to be both antigenic and complement-activating. Although it is not known whether eosinophil adherence has any larvicidal effect, the present study demonstrated for the first time a definite interaction between human eosinophils and hookworm filariform larvae.