Publication: In vitro and clinical evaluation of ofloxacin in urinary tract infection and enteric fever
Issued Date
1988-12-01
Resource Type
ISSN
03786501
Other identifier(s)
2-s2.0-0024227114
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Drugs under Experimental and Clinical Research. Vol.14, No.8 (1988), 529-531
Suggested Citation
D. Tanphaichitra, S. Srimuang In vitro and clinical evaluation of ofloxacin in urinary tract infection and enteric fever. Drugs under Experimental and Clinical Research. Vol.14, No.8 (1988), 529-531. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/15488
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
In vitro and clinical evaluation of ofloxacin in urinary tract infection and enteric fever
Author(s)
Other Contributor(s)
Abstract
During 1984 to 1988, 35 patients with urinary tract infction (UTI) and 37 patients with enteric fever were treated successfully with 400 mg ofloxacin twice a day for 7 to 10 days. Clinical cure or improvement was observed in 31 of the 35 patients with UTI; 32 patients were bacteriologically assessed and eradication was achieved in all of them. Ofloxacin was particularly effective in the treatment of enteric fever in 35 patients; eradication was achieved in all of them; 34 patients were clinically cured within 4 days, however, one patient with bacteraemia due to Salmonella paratyhi A subsequently died, due to his underlying disorder. The MIC 90 of the Enterobacteriaceae including Salmonella was less than 0.12 μg/ml. Interestingly, β-lactamase-producing strains of Salmonella and other Enterobacteriaceae in the present study were 28% and 29%, respectively. Ofloxacin therefore offers an effective b.i.d. dosage schedule for enteric fever and UTI due to β-lactamase-producing bacteria.