Publication: Cytoadherence of knobless Plasmodium falciparum-infected erythrocytes and its inhibition by a human monoclonal antibody
Issued Date
1989-01-01
Resource Type
ISSN
00280836
DOI
Other identifier(s)
2-s2.0-0024533419
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Nature. Vol.338, No.6218 (1989), 763-765
Suggested Citation
Rachanee Udomsangpetch, Masamichi Aikawa, Klavs Berzins, Mats Wahlgren, Peter Perlmann Cytoadherence of knobless Plasmodium falciparum-infected erythrocytes and its inhibition by a human monoclonal antibody. Nature. Vol.338, No.6218 (1989), 763-765. doi:10.1038/338763a0 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/15886
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Title
Cytoadherence of knobless Plasmodium falciparum-infected erythrocytes and its inhibition by a human monoclonal antibody
Abstract
RED blood cells infected with mature stages of the malaria parasite Plasmodium falciparum bind to the endothelial lining of capillaries and venules. This sequestration is important for the survival of the parasite but may have severe consequences for the host. For example, it is involved in the causation of cerebral malaria which carries 25% mortality 1-5 . Knob-like protrusions present on the surface of infected erythrocytes have been considered necessary but not sufficient for this cytoadherence 6-8 . Here we describe the adhesion to endothelial cells of infected erythrocytes which do not have knobs. A human monoclonal antibody (33G2) which was specific for an epitope containing regularly spaced dimers of glutamic acid present in the repeated amino-acid sequences of some definedP. falciparum antigens 9,10 was found to inhibit cytoadherence and may therefore be an important reagent for elucidating the molecular basis of parasite sequestration. © 1989 Nature Publishing Group.