Publication: Low folate status as a risk factor for cervical dysplasia in Thai women
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Issued Date
2005-07-01
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ISSN
02715317
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2-s2.0-24344469140
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Mahidol University
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SCOPUS
Bibliographic Citation
Nutrition Research. Vol.25, No.7 (2005), 641-654
Suggested Citation
Karunee Kwanbunjan, Phimonsri Saengkar, Cheeraratana Cheeramakara, Wanyarat Thanomsak, Wanpen Benjachai, Pikul Laisupasin, Kasinee Buchachart, Kriyaporn Songmuaeng, Naiyana Boontaveeyuwat Low folate status as a risk factor for cervical dysplasia in Thai women. Nutrition Research. Vol.25, No.7 (2005), 641-654. doi:10.1016/j.nutres.2005.05.004 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/16325
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Title
Low folate status as a risk factor for cervical dysplasia in Thai women
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Abstract
The relationship between folate status and the risk of cervical dysplasia was studied among Thai women. The subjects were composed of 44 women with low-grade cervical neoplasia (cervical intraepithelial neoplasm I), 70 women with high-grade cervical neoplasia (cervical intraepithelial neoplasm II, III, and carcinoma in situ), and 95 women who served as controls. The low folate status in these women showed a strong association with cervical dysplasia. Serum folate was markedly lower in both low-grade (P < .01) and high-grade cervical neoplasia cases (P < .01) compared with the control women. Using logistic regression, the odds ratio for low-grade cervical neoplasia with low serum folate level (<19.82 nmol/L) was 6.13, whereas that of the high-grade group with the same folate level was 5.57. The findings support the contention that folate deficiency of women in this study had an increased risk of cervical change. © 2005 Elsevier Inc. All rights reserved.