Publication: An anti-herpes simplex virus-type 1 agent from Xylaria mellisii (BCC 1005)
Issued Date
2005-02-21
Resource Type
ISSN
00404039
Other identifier(s)
2-s2.0-13244268386
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Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Tetrahedron Letters. Vol.46, No.8 (2005), 1341-1344
Suggested Citation
Pattama Pittayakhajonwut, Rapheephat Suvannakad, Surang Thienhirun, Samran Prabpai, Palangpon Kongsaeree, Morakot Tanticharoen An anti-herpes simplex virus-type 1 agent from Xylaria mellisii (BCC 1005). Tetrahedron Letters. Vol.46, No.8 (2005), 1341-1344. doi:10.1016/j.tetlet.2004.12.110 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/16373
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Title
An anti-herpes simplex virus-type 1 agent from Xylaria mellisii (BCC 1005)
Abstract
A structurally unique polyketide, mellisol (1) and 1,8-dihydroxynaphthol 1-O-α-glucopyranoside (3), were isolated from the fungus Xylaria mellisii (BCC 1005). The relative stereostructure of 1 was determined on the basis of X-ray crystallographic data. Compounds 1 and 3 exhibited activity against herpes simplex virus-type 1 with IC50values of 10.50 and 8.40 μg/mL, respectively. They also showed cytotoxic activity against vero cells at the concentration of 40-50 μg/mL. © 2004 Elsevier Ltd. All rights reserved.