Publication:
Synthesis of N-substituted isoindolinones via a palladium catalysed three-component carbonylation - amination - Michael addition cascade

2

Issued Date

2005-06-01

Resource Type

Article

ISSN

00084042

DOI

10.1139/v05-111

Other identifier(s)

2-s2.0-29244437147

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Canadian Journal of Chemistry. Vol.83, No.6-7 (2005), 990-1005

Suggested Citation

Ronald Grigg, Xinjie Gai, Tossapol Khamnaen, Shuleewan Rajviroongit, Visuvanathar Sridharan, Lixin Zhang, Simon Collard, Ann Keep Synthesis of N-substituted isoindolinones via a palladium catalysed three-component carbonylation - amination - Michael addition cascade. Canadian Journal of Chemistry. Vol.83, No.6-7 (2005), 990-1005. doi:10.1139/v05-111 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/16417

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Title

Synthesis of N-substituted isoindolinones via a palladium catalysed three-component carbonylation - amination - Michael addition cascade

Author(s)

Ronald Grigg
 Xinjie Gai
 Tossapol Khamnaen
 Shuleewan Rajviroongit
 Visuvanathar Sridharan
 Lixin Zhang
 Simon Collard
 Ann Keep

Other Contributor(s)

University of Leeds
 Mahidol University
 Johnson Matthey Plc

Abstract

We herein describe a novel palladium catalysed three-component cascade process involving carbonylation of an aryl iodide to generate an acyl palladium(II) species that is intercepted by a primary aliphatic or aromatic amine, amide, or sulfonamide followed by intramolecular Michael addition to furnish N-substituted isoindolinones in good yield. Overall, the cascade results in the formation of one C-C and two C-N bonds, one ring and one stereocentre. © 2005 NRC Canada.

Keyword(s)

Chemical Engineering
 Chemistry

Availability

URI

https://repository.li.mahidol.ac.th/handle/123456789/16417

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Scopus 2001-2005