Publication: Baseline correlation and comparative kinetics of cerebrospinal fluid colony-forming unit counts and antigen titers in cryptococcal meningitis
Issued Date
2005-08-15
Resource Type
ISSN
00221899
DOI
Other identifier(s)
2-s2.0-23244460544
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Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Infectious Diseases. Vol.192, No.4 (2005), 681-684
Suggested Citation
Annemarie E. Brouwer, Paprit Teparrukkul, Supraphada Pinpraphaporn, Robert A. Larsen, Wirongrong Chierakul, Sharon Peacock, Nicholas Day, Nicholas J. White, Thomas S. Harrison Baseline correlation and comparative kinetics of cerebrospinal fluid colony-forming unit counts and antigen titers in cryptococcal meningitis. Journal of Infectious Diseases. Vol.192, No.4 (2005), 681-684. doi:10.1086/432073 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/16561
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Title
Baseline correlation and comparative kinetics of cerebrospinal fluid colony-forming unit counts and antigen titers in cryptococcal meningitis
Abstract
Cerebrospinal fluid (CSF) cryptococcal colony-forming unit counts and CSF cryptococcal antigen titers serve as alternative measures of organism load in cryptococcal meningitis. For these measures, we correlated baseline values and rates of decline during the first 2 weeks of therapy in 68 human immunodeficiency virus-seropositive patients with cryptococcal meningitis. At baseline, there was a strong correlation between CSF cryptococcal colony-forming unit counts and CSF cryptococcal antigen titers. During the first 2 weeks of therapy, CSF cryptococcal colony-forming unit counts decreased by >5 logs, and CSF cryptococcal antigen titers decreased by 1.5 dilutions. In individual patients, there was no correlation between the rate of decline in CSF cryptococcal colony-forming unit counts and that in CSF cryptococcal antigen titers. © 2005 by the Infectious Diseases Society of America. All rights reserved.