Publication: The in vitro anti-giardial activity of extracts from plants that are used for self-medication by AIDS patients in southern Thailand
Issued Date
2005-01-01
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ISSN
09320113
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2-s2.0-12444282709
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Mahidol University
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SCOPUS
Bibliographic Citation
Parasitology Research. Vol.95, No.1 (2005), 17-21
Suggested Citation
N. Sawangjaroen, S. Subhadhirasakul, S. Phongpaichit, C. Siripanth, K. Jamjaroen, K. Sawangjaroen The in vitro anti-giardial activity of extracts from plants that are used for self-medication by AIDS patients in southern Thailand. Parasitology Research. Vol.95, No.1 (2005), 17-21. doi:10.1007/s00436-004-1264-8 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/16616
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Title
The in vitro anti-giardial activity of extracts from plants that are used for self-medication by AIDS patients in southern Thailand
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Abstract
This study evaluated the anti-giardial activity of chloroform, methanol and water extracts of 12 medicinal plants (39 extracts), commonly used as self medication by AIDS patients in southern Thailand. The plant extracts and a standard drug, metronidazole, were incubated with 2×105trophozoites of Giardia intestinalis per millilitre of growth medium in 96-well tissue culture plates under anaerobic conditions for 24 h. The cultures were examined with an inverted microscope and the minimum inhibitory concentration and the IC50value for each extract was determined. The chloroform extracts from Alpinia galanga, Boesenbergia pandurata, Eclipta prostrata, Piper betle, Piper chaba, Zingiber zerumbet, and the methanol extracts from B. pandurata and E. prostrata were classified as "active", i.e. with an IC50of < 100 μg/ml, whereas the chloroform extract from Murraya paniculata was classified as being "moderately active". This study shows that extracts from some medicinal plants have potential for use as therapeutic agents against G. intestinalis infections. © Springer-Verlag 2004.