Publication: Second-line drug susceptibilities of Thai multidrug-resistant Mycobacterium tuberculosis isolates
Issued Date
2005-02-01
Resource Type
ISSN
10273719
Other identifier(s)
2-s2.0-14044272121
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Mahidol University
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SCOPUS
Bibliographic Citation
International Journal of Tuberculosis and Lung Disease. Vol.9, No.2 (2005), 216-219
Suggested Citation
T. Prammananan, W. Arjratanakool, A. Chaiprasert, N. Tingtoy, M. Leechawengwong, N. Asawapokee, A. Leelarasamee, C. Dhiraputra Second-line drug susceptibilities of Thai multidrug-resistant Mycobacterium tuberculosis isolates. International Journal of Tuberculosis and Lung Disease. Vol.9, No.2 (2005), 216-219. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/17070
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Title
Second-line drug susceptibilities of Thai multidrug-resistant Mycobacterium tuberculosis isolates
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Abstract
The emergence of multidrug-resistant tuberculosis (MDR-TB) is increasing and is exacerbated by the human immunodeficiency virus (HIV) epidemic. The standard short-course regimen used for the treatment of tuberculosis is likely to be ineffective against MDR-TB, leading to the need for second-line drugs. In such situations, drug susceptibility testing (DST) is necessary to select an appropriate treatment regimen. In this study, DST of 99 MDR-TB strains isolated in Thailand was performed using a drug-impregnated disc method. The results showed that 94.95% of the strains were susceptible to amikacin and kanamycin, 90.91% to ciprofloxacin and ofloxacin, 85.86% to para-aminosalicylic acid, and 78.79% to ethionamide.