Publication: Genomic Aberrations in Human Hepatoblastomas Detected by 2-Dimensional Gel Analysis
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Issued Date
1995-10-15
Resource Type
ISSN
15387445
00085472
00085472
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2-s2.0-0028875208
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Mahidol University
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SCOPUS
Bibliographic Citation
Cancer Research. Vol.55, No.20 (1995), 4549-4551
Suggested Citation
Hisaki Nagai, Mathurose Ponglikitmongkol, Yong Sung Kim, Kenichi Matsubara, Hiroaki Tsumura, Mathurose Ponglikitmongkol, Yong Sung Kim Genomic Aberrations in Human Hepatoblastomas Detected by 2-Dimensional Gel Analysis. Cancer Research. Vol.55, No.20 (1995), 4549-4551. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/17237
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Title
Genomic Aberrations in Human Hepatoblastomas Detected by 2-Dimensional Gel Analysis
Abstract
Hepatoblastoma is a frequent embryonic tumor found in children. The mechanism of its formation and development remain unknown. We analyzed genomic DNA aberrations associated with three hepatoblastomas by means of restriction landmark genomic scanning (I. Hatada et aL, Proc. Natl. Acad. Sci. USA, 88:9523–9527, 1991). About 2000 Notl restriction landmarks were monitored in each of the hepatoblastomas, which revealed that the intensity of eight spots decreased in the tumor genome, suggesting allelic loss. Three of these spots were identical to those that decreased in human hepatocellular carcinomas. These results suggested that common, early events are involved in the genesis of the two types of liver tumor. © 1995, American Association for Cancer Research. All rights reserved.